/* body {
    background: url("/assets/beta_bg_tile.svg") repeat;
    background-size: 128px 128px;
} */

.container-xxl {
    max-width: 1320px;
}
.container-3xl {
    max-width: 1600px;
}
.border-1{
    border-width: 1px !important;
}
.border-2{
    border-width: 2px !important;
}
.border-3{
    border-width: 3px !important;
}
.border-4{
    border-width: 4px !important;
}
.border-5{
    border-width: 5px !important;
}

#page-content > .row > div:first-child {
    background-color: white;
}
ul.list-triangle {
    margin: 0.75rem 0;
    padding: 0 1rem;
    list-style: none;
}
ul.list-triangle li:before {
    content: "";
    border-color: transparent #111;
    border-style: solid;
    border-width: 0.35rem 0 0.35rem 0.45rem;
    display: block;
    height: 0;
    width: 0;
    left: -1rem;
    top: 1.1rem;
    position: relative;
}

ul.list-square {
    list-style-type: square;
    padding-left: 1rem;
    margin: 2rem 0;
}
ul.list-square li{
    margin: 0.75rem 0;
}

.navbar {
    border-bottom: 2px solid #e84e1b;
    background-color: #fff;
}

.navbar .navbar-nav .nav-item {
    border-bottom: 3px solid white;
    font-weight: 300;
}
.navbar .navbar-nav .nav-item:hover {
    border-bottom: 3px solid #FBE2DA;
}

.navbar .navbar-nav .nav-item .nav-link{
    color: #e84e1b;
    cursor: pointer;
    font-size: 14px;
}

.footer{
    border-top: 2px solid #e84e1b;
    background-color:#fff;
}

.footer hr{
    border-top: 2px solid #e84e1b;
}
.footer h4{
    font-size: 1.17em;
    font-weight: 300;
}
.footer ul{
    margin: 0 0 1em 1.2em;
    font-weight: 300;
}
.intro-big {
    /* background-image: url("/assets/neural-network-orange.jpg"); */
    background: rgb(255,255,255);
    background-size: cover;
    background-position-y: center;
    padding-top: 75px;
    padding-bottom: 30px;
    /* color: #f3f7fa; */
}

/* .intro-big > div {
    padding-left: 16.67%;
    padding-bottom: 20px;
    background-color: #02132355;
} */

.navbar a[target="_blank"]:after,
a.no-icon[target="_blank"]:after {
    display: none;
    content: "";
}

a[target="_blank"]:after {
    display: inline-block;
    content: "";
    background-image: url("data:image/svg+xml,<svg viewBox='0 0 16 16' fill='%23e84e1b' xmlns='http://www.w3.org/2000/svg'> <path fill-rule='evenodd' d='M8.636 3.5a.5.5 0 0 0-.5-.5H1.5A1.5 1.5 0 0 0 0 4.5v10A1.5 1.5 0 0 0 1.5 16h10a1.5 1.5 0 0 0 1.5-1.5V7.864a.5.5 0 0 0-1 0V14.5a.5.5 0 0 1-.5.5h-10a.5.5 0 0 1-.5-.5v-10a.5.5 0 0 1 .5-.5h6.636a.5.5 0 0 0 .5-.5z'/><path fill-rule='evenodd' d='M16 .5a.5.5 0 0 0-.5-.5h-5a.5.5 0 0 0 0 1h3.793L6.146 9.146a.5.5 0 1 0 .708.708L15 1.707V5.5a.5.5 0 0 0 1 0v-5z'/></svg>");
    background-repeat: no-repeat;
    background-size: 0.75rem 0.75rem;
    background-position-x: right;
    width: 1.05rem;
    height: 0.75rem;
}

#outer-wrapper{
    display: flex;
    flex-direction: column;
    min-height: 100vh;
}

#wrapper{
    flex: 1;
}
#explorer-sidebar{
    top: 30px;
    z-index: 10;
}


.table-buttons {
    margin-bottom: -2.34rem;
    padding-right: 152px;
}

.select-all-wrapper,
.export-selection-wrapper{
    position: relative;
    z-index: 10;
}

.dash-spreadsheet-menu {
    margin-bottom: 10px;
    justify-content: space-between;
}
.dash-spreadsheet-container .row{
    margin-left: 0;
    margin-right: 0;
}

.selection-table .dash-spreadsheet-menu {
    margin-left: 100px;
}
.selection-table .select-all{
    z-index: 10;
    /* position: relative;
    margin-bottom: -3.7rem */
}

.row .dash-table-container .dash-spreadsheet-container .dash-spreadsheet-inner table{
    font-family: -apple-system,BlinkMacSystemFont,"Segoe UI",Roboto,"Helvetica Neue",Arial,"Noto Sans",sans-serif,"Apple Color Emoji","Segoe UI Emoji","Segoe UI Symbol","Noto Color Emoji";
}
.row .dash-table-container .dash-spreadsheet-container .dash-spreadsheet-inner table th{
    font-weight: 400;
}

.donut {
    width: 100%; /* Size of the donut */
    height: 100%;
    border-radius: 50%;
    background: conic-gradient(#529a82 calc(var(--percentage) * 1%), #cbdcd5 0);
    display: flex;
    align-items: center;
    justify-content: center;
    position: relative;
  }
  
  .inner-circle {
    width: 80%; /* Adjust to control the thickness of the donut */
    height: 80%;
    border-radius: 50%;
    position: absolute;
    z-index: 1; /* Places it on top of the donut */
  }
  
  .donut-text {
    position: relative;
    z-index: 2; /* Ensures text appears above the inner circle */
  }

.dash-spreadsheet-menu button{
    display: inline-block;
    font-weight: 400;
    color: #212529;
    text-align: center;
    vertical-align: middle;
    user-select: none;
    background-color: transparent;
    border: 1px solid transparent;
        border-top-color: transparent;
        border-right-color: transparent;
        border-bottom-color: transparent;
        border-left-color: transparent;
    padding: .375rem .75rem;
    font-size: 1rem;
    line-height: 1.5;
    border-radius: .25rem;
    transition: color .15s ease-in-out,background-color .15s ease-in-out,border-color .15s ease-in-out,box-shadow .15s ease-in-out;
}
.row .dash-spreadsheet-menu .show-hide{
    color: #fdfffc;
    background-color: #f8b133;
    border-color: #f8b133;
    box-shadow: inset 0 1px 0 rgba(253,255,252,.15),0 1px 1px rgba(0,0,34,.075);
}
.row .dash-spreadsheet-menu .show-hide:hover,
.row .dash-spreadsheet-menu .show-hide:active{
    color: #fdfffc;
    background-color: #003555;
    border-color: #002d48;
}
.row .dash-spreadsheet-menu .export{
    color: #f8b133;
    border-color: #f8b133;;
}
.row .dash-spreadsheet-menu .export::after{
    content: " Full Table";
}
.row .dash-spreadsheet-menu .export:hover,
.row .dash-spreadsheet-menu .export:active{
    color: #fdfffc;
    background-color: #f8b133;
    border-color: #f8b133;
}

.row .dash-spreadsheet-menu .show-hide::after {
    display: inline-block;
    margin-left: .255em;
    vertical-align: .255em;
    content: "";
    border-top: .3em solid;
    border-right: .3em solid transparent;
    border-bottom: 0;
    border-left: .3em solid transparent;
}

.row .dash-spreadsheet-menu .dash-spreadsheet-menu-item .show-hide-menu{
    min-width: 10rem;
    padding: .5rem 0;
    margin: .125rem 0 0;
    font-size: 1rem;
    color: #212529;
    text-align: left;
    list-style: none;
    background-color: #fdfffc;
    background-clip: padding-box;
    border: 1px solid rgba(0,0,34,.15);
    border-radius: .25rem;
    box-shadow: 0 .5rem 1rem rgba(0,0,34,.175);
    min-width: 300px
}

.row .dash-spreadsheet-menu .dash-spreadsheet-menu-item .show-hide-menu .show-hide-menu-item{
    padding: .25rem 1.5rem .25rem 0.5rem;
    background-color: #fdfffc;
}
.row .dash-spreadsheet-menu .dash-spreadsheet-menu-item .show-hide-menu .show-hide-menu-item label{
    margin-bottom: 0
}
.row .dash-spreadsheet-menu .dash-spreadsheet-menu-item .show-hide-menu .show-hide-menu-item input{
    margin-right: 0.5rem;
}
.row .dash-spreadsheet-menu .dash-spreadsheet-menu-item .show-hide-menu .show-hide-menu-item:hover{
    background-color: #f8f9fa;
}
.dash-table-container .dash-spreadsheet-container .dash-spreadsheet-inner tr:first-child{
    position: sticky;
    top: 0;
}

th.dash-filter input[type="text"]{
    background: no-repeat url("filter.svg") right 5px center white !important;
    text-align: left !important;
    padding: 0 0 0 5px !important;
    border: 1px solid #f8b133 !important;
    border-radius: 2px !important;
}

.Select {
    white-space: pre-wrap;
    font-size: 0.8rem;
    cursor:pointer;
}

hr.light {
    border-top: 1px solid rgba(255, 255, 255, 0.25);
    width: 100%
}

#drug-advanced-options p:last-child,
#crispr-advanced-options p:last-child{
    padding-bottom: 0;
    margin-bottom: 0;
}


.dash-dot-spinner > div{
    background-color: #004d7b !important;
}


.notification-toast.toast{
    /* position: fixed;
    top: 66px;
    right: 10px;
    width: 350px;
    z-index: 11; */
    background-color: white;
    box-shadow: 0 19px 38px rgba(0,0,0,0.30), 0 15px 12px rgba(0,0,0,0.22);

}
.notification-toast .toast-header{
    justify-content: space-between;
}

.extra-small{
    font-size: 60%
}
.main-filters-combine-label {
    color: #e84e1b;
}
.main-filters-combine-dropdown.Select--single > .Select-control{
    border: 1px solid #f8b133;
}
.main-filters-combine-dropdown.Select--single>.Select-control .Select-value .Select-value-label{
    color: #e84e1b;
    font-weight: bold;
}
.main-filters-combine-dropdown.Select--single>.Select-control .Select-arrow{
    border-top-color: #e84e1b;
}
.method-sidebar {
    margin-left: -1px;
    margin-top: -1px;
    border: 1px solid #dee2e6;
    border-bottom-width: 0px;
}
.method-sidebar.list-group-flush > .list-group-item:last-child{
    border-bottom-width: 1px;
}

.method-sidebar.list-group-flush > .list-group-item{
    /* color: #15a57b; */
    color: #e84e1b;
}
.method-sidebar.list-group-flush > .list-group-item .small{
    color: #6c757d;
}
.method-sidebar.list-group-flush > .list-group-item.active{
    /* color: #212529; */
    /* background-color: #f3f7fa; */
    background-color: #f8b13311;
    font-weight: bold;
}

.method-sidebar.list-group-flush > .list-group-item.active::after {
    border-color: transparent transparent transparent #f3f7fa;
    border-style: solid;
    border-width: 20px;
    content: "";
    position: absolute;
    right: -40px;
    top: 4px;
}

@media (min-width: 1400px) { 
    .method-sidebar.list-group-flush > .list-group-item.active::after {
        top: 15px;
    }
}

.content-wrapper{
    margin-left:-16px;

}

.drug-wrapper{
    margin-right: -1px;
    margin-bottom: -1px;
}
.page-text h3{
    margin-top: 2rem;
}

.bg-primary-light{
    background-color: #f3f7fa;
}

.page-form-wrapper{
    border-radius: 5px;
}

.shadow-1{
    box-shadow: 0 1px 3px rgba(0,0,0,0.12), 0 1px 2px rgba(0,0,0,0.24);
}
.shadow-2{
    box-shadow: 0 3px 6px rgba(0,0,0,0.16), 0 3px 6px rgba(0,0,0,0.23);
}
.shadow-3{
    box-shadow: 0 10px 20px rgba(0,0,0,0.19), 0 6px 6px rgba(0,0,0,0.23);
}
.shadow-4{
    box-shadow: 0 14px 28px rgba(0,0,0,0.25), 0 10px 10px rgba(0,0,0,0.22);
}
.shadow-5{
    box-shadow: 0 19px 38px rgba(0,0,0,0.30), 0 15px 12px rgba(0,0,0,0.22);
}

.highlight .Select-control{
    border: 1px solid #f8b133;
    box-shadow: 0 0 2px #f8b133;
    background-color:  #f8b13305;
}
.highlight .Select-placeholder{
    color: #6c757d;
}

th.dash-filter{
    border: 1px solid #f8b133;
    box-shadow: 0 0 2px #f8b133;
    background-color:  #f8b13305;
}


.leading-relaxed {
    line-height: 1.625rem;
}


.fadein{
    animation: fadeIn ease 2s;
    color: #6c757d;
}
.fadein2{
    animation: fadeIn2 ease 2s;
    color: #6c757d;
}
@keyframes fadeIn {
    0% {opacity:1; color: transparent; background-color: transparent}
    25% {opacity: 1; color: black; background-color: #fddba1}
    100% {opacity:1; color: #6c757d; background-color: transparent}
}
@keyframes fadeIn2 {
0% {opacity:1; color: transparent; background-color: transparent}
25% {opacity: 1; color: black; background-color: #fddba1 }
100% {opacity:1; color: #6c757d; background-color: transparent}
}

.single-filter-wrapper p{
    line-height: 1rem
}

#biomarker-volcano-plot rect.nsewdrag.drag{
    cursor: pointer;
}

.text-lg {
    font-size:125%
}
.text-xs {
    font-size: 75%;
    line-height: normal;
}
.text-grey {
    color: #6c757d;
}
.column-header--hide {
    display: none;
}

.dash-cell .cell-markdown p{
    margin-bottom: 0;
}

#changelog tr:first-child td {
    border-top: none;
}